Genspect is an international organization advocating for holistic, evidence-based, non-medical approaches to gender distress. It represents clinicians, researchers, parents, detransitioners, and others who are concerned about the rapid medicalization of gender-questioning children and adolescents under the "gender affirming care" model. Genspect Canada is the Canadian chapter, directed by journalist and researcher Mia Hughes.

Genspect's core position is that gender dysphoria — particularly the rapid-onset variety now predominant among adolescent females — is best addressed through careful psychological assessment, treatment of co-occurring conditions such as depression, anxiety, autism, and trauma, and support for natural development. The organization argues that immediate medical affirmation and early intervention with puberty blockers and cross-sex hormones lacks an adequate evidence base and causes irreversible harm to a significant proportion of those treated.

Genspect publishes research, produces educational content, and supports healthcare professionals seeking to practice evidence-based medicine in this area without fear of ideological pressure. Mia Hughes and Genspect founder Stella O'Malley co-host the podcast Beyond Gender, which explores these issues with clinicians, researchers, and those with lived experience.